Samento - Microbial Defense

ALZHEIMER’S DISEASE

Researchers Report That a Natural Plant Derivative From the Amazon Rain Forest in a Rodent Model Inhibits the Deposition of Beta-amyloid Deposits Associated With Alzheimer's Disease Plaques.. (n.d.) >The Free Library. (2014). Retrieved Jun 20 2018 from Full Article

BLADDER CANCER

Dietrich, F., Kaiser, S., Rockenbach, L., Figueiró, F., Bergamin, L. S., da Cunha, F. M., ... & Battastini, A. M. O. (2014). Quinovic acid glycosides purified fraction from Uncaria tomentosa induces cell death by apoptosis in the T24 human bladder cancer cell line. Food and chemical toxicology, 67, 222-229. Full Article

BRAIN CANCER

Prado, E. G., Gimenez, M. G., De la Puerta Vázquez, R., Sánchez, J. E., & Rodriguez, M. S. (2007).Antiproliferative effects of mitraphylline, a pentacyclic oxindole alkaloid of Uncaria tomentosa on human glioma and neuroblastoma cell lines. Phytomedicine, 14(4), 280-284. Full Article

BREAST CANCER

Baraya, Y. U. S. A. B., Wong, K. K., & Yaacob, N. S. (2017). The immunomodulatory potential of selected bioactive plant-based compounds in breast cancer: a review. Anti-Cancer Agents in Medicinal Chemistry(Formerly Current Medicinal Chemistry-Anti-Cancer Agents), 17(6), 770-783. Full Article

García Giménez, M. D., García Prado, E., Sáenz Rodríguez, M. T., Fernández Arche, M. D. L. Á., & Puerta Vázquez-Zafra, R. D. L. (2010). Cytotoxic effect of the pentacyclic oxindole alkaloid mitraphylline isolated from Uncaria tomentosa bark on human Ewing's sarcoma and breast cancer cell lines. Planta Medica, 76, 133-136. Full Article

Riva, L., Coradini, D., Di, G. F., De, V. F., De, N. T., De, F. S., & Pizza, C. (2001). The antiproliferative effects of Uncaria tomentosa extracts and fractions on the growth of breast cancer cell line. Anticancer Research, 21(4A), 2457-2461. Full Article

CYSTITIS

Dietrich, F., Martins, J. P., Kaiser, S., Silva, R. B. M., Rockenbach, L., Edelweiss, M. I. A., ... & Battastini, A. M. O. (2015). The quinovic acid glycosides purified fraction from Uncaria tomentosa protects against hemorrhagic cystitis induced by cyclophosphamide in mice. PloS one, 10(7), e0131882. Full Article

DENGUE FEVER

Reis, S. R. I., Valente, L. M., Sampaio, A. L., Siani, A. C., Gandini, M., Azeredo, E. L., ... & Kubelka, C. F. (2008). Immunomodulating and antiviral activities of Uncaria tomentosa on human monocytes infected with Dengue Virus-2. International Immunopharmacology, 8(3), 468-476. Full Article

DENTURE STOMATITIS

Tay, L. Y., Dos Santos, F. A., & Jorge, J. H. (2015). Uncaria tomentosa gel against denture stomatitis: clinical report. Journal of Prosthodontics, 24(7), 594-597. Full Article

ENDOMETRIOSIS

Neto, J. N., Coelho, T. M., Aguiar, G. C., Carvalho, L. R., de Araújo, A. G. P., Girão, M. J. B., & Schor, E. (2011).Experimental endometriosis reduction in rats treated with Uncaria tomentosa (cat's claw) extract. European Journal of Obstetrics and Gynecology and Reproductive Biology, 154(2), 205-208. Full Article

HERPES

Caon, T., Kaiser, S., Feltrin, C., de Carvalho, A., Sincero, T. C. M., Ortega, G. G., & Simões, C. M. O. (2014).Antimutagenic and antiherpetic activities of different preparations from Uncaria tomentosa (cat’s claw). Food and Chemical Toxicology, 66, 30-35. Full Article

IMMUNE-MEDIATED DISEASES (DIABETES)                   

Domingues, A., Sartori, A., Golim, M. A., Valente, L. M. M., da Rosa, L. C., Ishikawa, L. L. W., ... & Viero, R. M. (2011). Prevention of experimental diabetes by Uncaria tomentosa extract: Th2 polarization, regulatory T cell preservation or both?. Journal of Ethnopharmacology, 137(1), 635-642. Full Article

LEUKEMIA

Pilarski, R., Poczekaj-Kostrzewska, M., Ciesiolka, D., Szyfter, K., & Gulewicz, K. (2007). Antiproliferative activity of various Uncaria tomentosa preparations on HL-60 promyelocytic leukemia cells. Pharmacological reports, 59(5), 565. Full Article

LISTERIA

Eberlin, S., dos Santos, L. M., & Queiroz, M. L. (2005). Uncaria tomentosa extract increases the number of myeloid progenitor cells in the bone marrow of mice infected with Listeria monocytogenes. International Immunopharmacology, 5(7-8), 1235-1246. Full Article

LYME DISEASE

Datar, A. N., Kaur, N., Patel, S., Luecke, D. F., & Sapi, E. (2010). In Vitro Effectiveness of Samento and Banderol Herbal Extracts on Different Morphological Forms of Borrelia Burgdorferi (Doctoral dissertation, University of New Haven). Full Article

OSTEOARTHRITIS

Piscoya, J., Rodriguez, Z., Bustamante, S. A., Okuhama, N. N., Miller, M. J. S., & Sandoval, M. (2001). Efficacy and safety of freeze-dried cat's claw in osteoarthritis of the knee: mechanisms of action of the species Uncaria guianensis. Inflammation Research, 50(9), 442-448. Full Article

RHEUMATOID ARTHRITIS

Mur, E., Hartig, F., Eibl, G., & Schirmer, M. (2002). Randomized double-blind trial of an extract from the pentacyclic alkaloid-chemotype of uncaria tomentosa for the treatment of rheumatoid arthritis. The Journal of Rheumatology, 29(4), 678-681. Full Article

SKIN CANCER

Ciani, F., Tafuri, S., Troiano, A., Cimmino, A., Fioretto, B. S., Guarino, A. M., ... & Calabrò, V. (2018). Anti-proliferative and pro-apoptotic effects of Uncaria tomentosa aqueous extract in squamous carcinoma cells.Journal of Ethnopharmacology, 211, 285-294. Full Article

THYROID CANCER

Rinner, B., Li, Z. X., Haas, H., Siegl, V., Sturm, S., Stuppner, H., & Pfragner, R. (2009). Antiproliferative and pro-apoptotic effects of Uncaria tomentosa in human medullary thyroid carcinoma cells. Anticancer Research, 29(11), 4519-4528. Full Article

TUMORS

Santos, K. F., Gutierres, J. M., Pillat, M. M., Rissi, V. B., dos Santos Araújo, M. D. C., Bertol, G., ... & Morsch, V. M. (2016). Uncaria tomentosa extract alters the catabolism of adenine nucleotides and expression of ecto-5′-nucleotidase/CD73 and P2X7 and A1 receptors in the MDA-MB-231 cell line. Journal of Ethnopharmacology,194, 108-116. Full Article

de Paula, L. C. L., Fonseca, F., Perazzo, F., Cruz, F. M., Cubero, D., Trufelli, D. C., ... & del Giglio, A. (2015).Uncaria tomentosa (cat's claw) improves quality of life in patients with advanced solid tumors. The Journal of Alternative and Complementary Medicine, 21(1), 22-30. Full Article

Dreifuss, A. A., Bastos-Pereira, A. L., Ávila, T. V., da Silva Soley, B., Rivero, A. J., Aguilar, J. L., & Acco, A. (2010).Antitumoral and antioxidant effects of a hydroalcoholic extract of cat's claw (Uncaria tomentosa)(Willd. Ex Roem. & Schult) in an in vivo carcinosarcoma model. Journal of Ethnopharmacology, 130(1), 127-133. Full Article

ADJUNCTIVE TO CHEMOTHERAPY

Allen, L., Buckner, A., Buckner, C. A., Cano, P., & Lafrenie, R. M. (2017). Uncaria tomentosa (Willd. ex Schult.) DC (Rubiaceae) sensitizes THP-1 cells to radiation-induced cell death. Pharmacognosy Research, 9(3), 221. Full Article

Farias, I., do Carmo Araújo, M., Zimmermann, E. S., Dalmora, S. L., Benedetti, A. L., Alvarez-Silva, M., ... & Schetinger, M. R. C. (2011). Uncaria tomentosa stimulates the proliferation of myeloid progenitor cells. Journal of Ethnopharmacology, 137(1), 856-863. Full Article

ANTIBACTERIAL

Nowakowska, J., Bany, J., Zdanowska, D., Czubaj, A., Kuraś, M., & Skopińska-Różewska, E. (2009). Experimental Immunology: The effect of the bark water extract Uncaria tomentosa on the Pseudomonas aeruginosa infection in mice. Central European Journal of Immunology, 34(3), 162-165. Full Article

ANTIFUNGAL

Moraes, R. C., Carvalho, A. R., Lana, A. J. D., Kaiser, S., Pippi, B., Fuentefria, A. M., & Ortega, G. G. (2017). In vitro synergism of a water insoluble fraction of Uncaria tomentosa combined with fluconazole and terbinafine against resistant non-Candida albicans isolates. Pharmaceutical biology, 55(1), 406-415. Full Article

Moraes, R. C., Dalla Lana, A. J., Kaiser, S., Carvalho, A. R., de Oliveira, L. F. S., Fuentefria, A. M., & Ortega, G. G. (2015). Antifungal activity of Uncaria tomentosa (Willd.) DC against resistant non-albicans Candida isolates.Industrial Crops and Products, 69, 7-14. Full Article

ANTI-INFLAMMATORY

Montserrat-de la Paz, S., Fernandez-Arche, A., de la Puerta, R., Quilez, A. M., Muriana, F. J., Garcia-Gimenez, M. D., & Bermudez, B. (2016). Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils. Phytomedicine, 23(2), 141-148. Full Article

Rojas-Duran, R., González-Aspajo, G., Ruiz-Martel, C., Bourdy, G., Doroteo-Ortega, V. H., Alban-Castillo, J., ... & Deharo, E. (2012). Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa bark. Journal of Ethnopharmacology, 143(3), 801-804. Full Article

Gonçalves, C., Dinis, T., & Batista, M. T. (2005). Antioxidant properties of proanthocyanidins of Uncaria tomentosa bark decoction: a mechanism for anti-inflammatory activity. Phytochemistry, 66(1), 89-98. Full Article

ANTIGENOTOXIC AND ANTIMUTAGENIC

Paniagua‐Pérez, R., Madrigal‐Bujaidar, E., Molina‐Jasso, D., Reyes‐Cadena, S., Álvarez‐González, I., Sánchez‐Chapul, L., & Pérez‐Gallaga, J. (2009). Antigenotoxic, antioxidant and lymphocyte induction effects produced by pteropodine. Basic & clinical pharmacology & toxicology, 104(3), 222-227. Full Article

ANTIMICROBIAL

Herrera, D. R., Tay, L. Y., Rezende, E. C., Kozlowski Jr, V. A., & dos Santos, E. B. (2010). In vitro antimicrobial activity of phytotherapic Uncaria tomentosa against endodontic pathogens. Journal of oral science, 52(3), 473-476. Full Article

ANTINEOPLASTIC

Dreifuss, A. A., Bastos-Pereira, A. L., Fabossi, I. A., dos Reis Lívero, F. A., Stolf, A. M., de Souza, C. E. A., ... & Teixeira, S. (2013). Uncaria tomentosa exerts extensive anti-neoplastic effects against the Walker-256 tumor by modulating oxidative stress and not by alkaloid activity. PLoS One, 8(2), e54618. Full Article

Rinner, B., Li, Z. X., Haas, H., Siegl, V., Sturm, S., Stuppner, H., & Pfragner, R. (2009). Antiproliferative and pro-apoptotic effects of Uncaria tomentosa in human medullary thyroid carcinoma cells. Anticancer research, 29(11), 4519-4528. Full Article

ANTIOXIDANT

Bukowska, B., Bors, M., Gulewicz, K., & Koter-Michalak, M. (2012). Uncaria tomentosa extracts protect human erythrocyte catalase against damage induced by 2, 4-D-Na and its metabolites. Food and Chemical Toxicology, 50(6), 2123-2127. Full Article

Amaral, S., Mira, L., Nogueira, J. M. F., da Silva, A. P., & Florêncio, M. H. (2009). Plant extracts with anti-inflammatory properties—A new approach for characterization of their bioactive compounds and establishment of structure-antioxidant activity relationships. Bioorganic & Medicinal Chemistry, 17(5), 1876-1883. Full Article

Trejo‐Tapia, G., Sepúlveda‐Jiménez, G., Trejo‐Espino, J. L., Cerda‐García‐Rojas, C. M., De La Torre, M., Rodríguez‐Monroy, M., & Ramos‐Valdivia, A. C. (2007). Hydrodynamic stress induces monoterpenoid oxindole alkaloid accumulation by Uncaria tomentosa (Willd) DC cell suspension cultures via oxidative burst. Biotechnology and Bioengineering, 98(1), 230-238. Full Article

Cisneros, F. J., Jayo, M., & Niedziela, L. (2005). An Uncaria tomentosa (cat's claw) extract protects mice against ozone-induced lung inflammation. Journal of Ethnopharmacology, 96(3), 355-364. Full Article

CENTRAL NERVOUS SYSTEM (CNS) SUPPORT

Kang, T. H., Matsumoto, K., Tohda, M., Murakami, Y., Takayama, H., Kitajima, M., ... & Watanabe, H. (2002). Pteropodine and isopteropodine positively modulate the function of rat muscarinic M1 and 5-HT2 receptors expressed in Xenopus oocyte. European journal of pharmacology, 444(1-2), 39-45. Full Article

CYTOPROTECTIVE

Sandoval, M., Charbonnet, R. M., Okuhama, N. N., Roberts, J., Krenova, Z., Trentacosti, A. M., & Miller, M. J. (2000). Cat’s claw inhibits TNFα production and scavenges free radicals: role in cytoprotection. Free Radical Biology and Medicine, 29(1), 71-78. Full Article

IMMUNOMODULATING

Lozada-Requena, I., Núñez, C., Alvárez, Y., Kahn, L., & Aguilar, J. (2015). Lymphocyte subsets, dendritic cells and cytokine profiles in mice with melanoma treated with Uncaria tomentosa. Revista Peruana de Medicina Experimental y Salud Publica, 32(4), 633-642. (Spanish). Full Article

Núñez, C., Lozada-Requena, I., Ysmodes, T., Zegarra, D., Saldaña, F., & Aguilar, J. (2015). Immunomodulation of Uncaria tomentosa over dendritic cells, il-12 and profile TH1/TH2/TH17 in breast cancer. Revista Peruana de Medicina Experimental y Salud Publica, 32(4), 643-651. Full Article

Montserrat-De La Paz, S., De la Puerta, R., Fernandez-Arche, A., Quilez, A. M., Muriana, F. J. G., Garcia-Gimenez, M. D., & Bermudez, B. (2015). Pharmacological effects of mitraphylline from Uncaria tomentosa in primary human monocytes: skew toward M2 macrophages. Journal of Ethnopharmacology, 170, 128-135. Full Article

Domingues, A., Sartori, A., Valente, L. M. M., Golim, M. A., Siani, A. C., & Viero, R. M. (2011). Uncaria tomentosa Aqueous‐ethanol Extract Triggers an Immunomodulation toward a Th2 Cytokine Profile. Phytotherapy Research, 25(8), 1229-1235. Full Article

Kang, T. H., Matsumoto, K., Tohda, M., Murakami, Y., Takayama, H., Kitajima, M., ... & Watanabe, H. (2002).Pteropodine and isopteropodine positively modulate the function of rat muscarinic M1 and 5-HT2 receptors expressed in Xenopus oocyte. European Journal of Pharmacology, 444(1-2), 39-45. Full Article

Karl-Heinz Reinhard (1999). Uncaria tomentosa (Willd.) D.C.: Cat's Claw, Una de Gato, or Saventaro. The Journal of Alternative and Complementary Medicine, pp. 143-151 Full Article

LYME DISEASE

Why this Finnish Doctor Believes in Herbs, Marjo Valonen MD, Townsend Letter, July 2018 Full Article

A Hidden Epidemic: Integrative Treatment of Lyme Disease, Scott Forsgren, March 2009 Full Article

Chronic Fatigue Often Misdiagnosed Lyme: Is Samento An Answer?, Complementary and Alternative Medicine, October 2004. Full Article

Samento: New Remedy for an Ancient Enemy—Lyme Disease, James South, Vitamin Research News, Vol. 18, Number 6, July 2004. Full Article

RHEUMATOID ARTHRITIS                                                                                             

Live Blood Analysis: Treatment of Rheumatoid Arthritis, Arthritis and Colon Cancer with Samento (2002), Professor Henk Oswald, M.D., Ph.D., Amsterdam, Netherlands. Full Article

VARIOUS MEDICAL CONDITIONS

Samento in the Primary Care Setting, John Kule, MD. British Naturopathic Journal, Vol. 19, No. 2, 2002. Full Article

Why Samento Successfully Treats Over 100 Diseases, Atanas Tzonkov, Director of Lechitel Health Center,Lechitel Weekly, April 2002. Full Article