NEUROCLIMAX 13ml
Ρινικό εκνέφωμα με Forskolin για την βελτίωση των λειτουργιών του εγκεφάλου. Μοναδική πατενταρισμένη φόρμουλα απο το τμήμα νευροεπιστημών του πανεπιστημίου του Reno στην Νεβάδα της Αμερικής. Απορροφάται μέσω του οσφρητικού νεύρου, διεγείρει την παραγωγή ντοπαμίνης & τον μηχανισμό απομάκρυνσης παθολογικών πρωτεΐνων. Βελτιώνει τις κινητικές & γνωστικές δεξιότητες, τη μνήμη, το λόγο και τον ύπνο.
Κλινικές μελέτες :
- - Pre-clinical science on nasal nootropic formulation against Lewy Body dementia in Parkinsons disease
Dagda, Ruben & Dagda, Raul & Mayorga, Emmanuel & Martinez, Bridget & Gallahue, Aine. (2022). Intranasal Administration of Forskolin and Noopept Reverses Parkinsonian Pathology in PINK1 Knockout Rats. International Journal of Molecular Sciences. 24. 690. 10.3390/ijms24010690.
- - Patented pharmaceutical technology against LewyBody dementia Parkinson's disease
US11612583B2: "Disease modifying methods for treating neurodegenerative diseases using nootropic agents" Raul Y Dagda, and Ruben K. Dagda
- - National Science foundation I-corps awards to CNS Curative Technologies: Patients interviews for medical necessities for NeuroClimax development
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2135052
- - Vazquez-Mayorga E, Grigoruta M, Dagda R, Martinez B, Dagda RK. Intraperitoneal Administration of Forskolin Reverses Motor Symptoms and Loss of Midbrain Dopamine Neurons in PINK1 Knockout Rats. J Parkinsons Dis. 2022;12(3):831-850. doi: 10.3233/JPD-213016. PMID34957950;
- - PMCID: PMC9108570.Soman SK, Tingle D, Dagda RY, Torres M, Dagda M, Dagda RK. Cleaved PINK1 induces neuronal plasticity through PKA-mediated BDNF functional regulation. J Neurosci Res. 2021 Sep;99(9):2134-2155. doi: 10.1002/jnr.24854. Epub 2021 May 27. PMID: 34046942; PMCID: PMC8513622.
- - Swain, M., Dagda, R.Y., Soman, S., Tapia, K., Dagda, RK.K. Brain-Derived Neurotrophic Factor protects neurons by stimulating mitochondrial function through Protein Kinase A, 2023, In-Press, Journal of Neurochemistry
- Seamon K.B., Padgett W., Daly J.W. Forskolin unique diterpene activator of adenylate cyclase in membranes and in intact cells. Proc. Natl. Acad. Sci. USA. 1981;78:3363–3367. doi: 10.1073/pnas.78.6.3363.
- Owona B.A., Zug C., Schluesener H.J., Zhang Z.Y. Protective Effects of Forskolin on Behavioral Deficits and Neuropathological Changes in a Mouse Model of Cerebral Amyloidosis. J. Neuropathol. Exp. Neurol. 2016;75:618–627. doi: 10.1093/jnen/nlw043.
- Sangeetha S., Samanta M.K., Manjunatha N., Tiwari S. Establishment of Pharmacokinetic Parameters for the Herbal Drug Containing Forskolin. J. Pharm. Res. 2011;4:2303–2306.
