METHYL COMPLETE 120caps

Ολοκληρωμένη φόρμουλα για την υποστήριξη της υγιούς μεθυλίωσης του DNA. Η βιοχημική διεργασία που περιλαμβάνει την προσθήκη μιας μεθυλομάδας (-CH3) σε διάφορες απαραίτητες βιοχημικές ενώσεις.* Η υγιής μεθυλίωση τροφοδοτείται από αποτελεσματικούς κύκλους φολικού και μεθειονίνης, οι οποίοι εξαρτώνται από το ενεργό φυλλικό οξύ (5-MTHF) και την ενεργή βιταμίνη Β12 (μεθυλοκοβαλαμίνη). Βασικοί συμπαράγοντες όπως η βιταμίνη Β2 (ριβοφλαβίνη) και η δραστική Β6 (P5P), επαρκείς δότες μεθυλίου και αποτελεσματική μετατροπή της ομοκυστεΐνης, είτε ανακυκλώνεται ξανά σε μεθειονίνη είτε μετατρέπεται σε κυστεΐνη με τη βοήθεια της Β6 (P5P) και τελικά στη γλουταθειόνη.

Δεν περιέχει γαλακτοκομικά, σόγια, γλουτένη, ζάχαρη, μαγιά και μούχλα.

METHYLATION SUPPORT

Methylation, the addition of methyl groups (-CH3), is essential to processes as varied as DNA replication, neurotransmitter production, antioxidant activity, and healthy detoxification, among others.* Normal methylation can be challenged by various factors, including a lack of B vitamins and cofactors; an inability to convert B vitamins and cofactors to their active forms, resulting in a lack of methyl donors; and various single-nucleotide polymorphisms (SNPs) which may affect methylation efficiency. Supplementation with B vitamins, particularly in their active forms, may help to support normal methylation, bypassing the need for conversion; help maintain homocysteine levels already within the normal range; and help maintain glutathione levels already within the normal range, supporting normal detoxification.* Efficient methylation may support normal cellular metabolism, as well as healthy energy production and storage.* Normal levels of homocysteine are associated with normal antioxidant activity, a healthy inflammatory response, and normal cognitive and cardiovascular health.*11 Vitamin B2 is required for the conversion of vitamin B6 to the active form P5P;1 it is also a cofactor for MTHFR, the enzyme that converts folic acid to active methylfolate in the folate cycle. Both methylfolate and methylcobalamin (B12) help to recycle homocysteine to methionine, which is then converted to S-adenosylmethionine (SAM-e), the body’s universal methyl donor.12 Adequate levels of SAM-e may help to stabilize BH4 in the biopterin cycle, maintaining neurotransmitters such as MAO and serotonin already within the normal range.*13 SAM-e may also help to maintain homocysteine levels already within the normal range.*14 After donating a methyl group, SAM-e converts to homocysteine, which can either be recycled back to methionine with the help of methylfolate or methylcobalamin (B12),15 or converted to cysteine through the transsulfuration pathway with the help of cofactor P5P (B6), supporting normal glutathione production and helping with healthy antioxidant support.*16 Vitamin B6 is needed for the folate cycle, the transsulfuration pathway, and methylation.17 In this formula, it is present in the active form of pyridoxal 5'-phosphate (P5P), which does not rely on the body’s ability to convert it. Vitamin B6 may help with folate recycling and may help to maintain homocysteine levels already within the normal range.*18,19 Vitamin B12 is in the active form of methylcobalamin, the other active form being adenosylcobalamin. As a methyl donor, methylcobalamin may help to maintain normal methylation, independent of MTHFR status, as it is not reliant on the body’s ability to convert it. B12 is needed for both the folate cycle and the methionine cycle, the latter of which is responsible for making SAM-e.20 In the active form of Calcium L-Methylfolate, folate helps to make SAM-e, the body’s universal methyl donor, via the methionine cycle.12.17 As such, SAM-e is involved in a number of processes, including the synthesis of creatine, which is made from the transamination of amino acids arginine, glycine, and methionine.21 This methylation support formula includes creatine, which may help to spare SAM-e for other purposes.* Creatine monohydrate may also help with methylation support.*7 It is generated by the methionine cycle, and both rat and human studies have found that it may help to maintain homocysteine levels already within the normal range and may help with antioxidant support.*22,7 A double-blind, placebo-controlled human study found that creatine may help to maintain normal energy homeostasis in the brain, supporting healthy cognition.*23 As 40% of the methyl groups produced as SAM-e are used for creatine synthesis, supplemental creatine may help spare some of these to be used for other purposes.*24 Betaine anhydrous, also known as trimethylglycine (TMG), occurs naturally in the body from the oxidation of choline and is a cofactor in the recycling of homocysteine to methionine.*25 As such, betaine anhydrous may act on the methionine cycle to maintain levels of homocysteine already within the normal range.*9,10

2 κάψουλες 2 φορές την ημέρα μετά τα γεύματα ή σύμφωνα με τις οδηγίες του γιατρού.

Αντενδείξεις: Δεν επιτρέπεται η κατανάλωση σε εγκύους και θηλάζουσες.

Ανά Δόση (2 κάψουλες):
Vitamin B2 (as riboflavin) 20 mg (1538 % NRV)
Vitamin B6 (as pyridoxine-5-phosphate) 20 mg (1176 % NRV)
Folate (as calcium L-methyl-Folate) 400 yg (100 % NRV)
Vitamin B12 (as Methylcobalamin) 100 yg (4167 % NRV)
Creatine Monohydrate 500 mg
Betaine (Trimethylglycine) 500 mg

Other Ingredients: Vegetarian capsule shell, microcrystalline cellulose, magnesium stearate, silicone dioxide
Free of gluten, sugar and dairy ingredients.

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